Essay On Stem Cell Therapy - 814 Words

†¢ Hai Nguyen, Aileen Anderson and colleagues: carried a similar exercise on injured mice to record tremendous success of the donor cells in a period ranging immediately after the induction process to at most one month (Society for Neuroscience. 2017). †¢ Scientists from the Cedars-Sinai Heart Institute in Los Angeles CA: highlighted the need for stem therapy in replacing aging heart muscles using rats (Paddock, 2017). The induced cells were able to grow and multiply thus repair the heart muscles of the older rats to improve the general body functioning. Despite the breathtaking discoveries as tested and presented by these scientists, ethical concerns have prevailed to the dismay of an excited global scientists’ fraternity. The general†¦show more content†¦As a result, the situation provides conflict of interest, especially when such an adult/ guardian is the patient in need. Lo and Parham argument regarding Embryonic stem cell research bears the same weight with regards to children because the advocates for or against the practice are adults thus leaving the children vulnerable, as the potential donors. The excitement surrounding Stem Cell Research is magnified through mainstream media that often cares about moving volumes in sales rather than realistically highlight the caution or reservations pronounced by scientists. However, Sharon Begley is exemplary in her revelation of a high-risk gap in research that links Stem Cell Studies to development or transmission of cancer (2017). Most research initiatives adopt a subjective operation that intends to consider side-effects only after the desired findings are confirmed a success. That is the reason most research reports spend limited time on challenges and often use the loophole of proposing ‘future studies’, to cover the potential weaknesses of their current work. Such is the case of the human embryonic stem cell lines under the custody of the National Institute of Health as sampled by Harvard Scientists (Begley, 2017). The samples are intended for active therapy and also future research on application in treating disease s including; Parkinson’s disease, macular degeneration and diabetes.Show MoreRelated Stem Cell Therapy for Diabetes Essay1151 Words   |  5 PagesDiabetes, or fully named Diabetes Mellitus is when a person has high blood sugar and that is cause by the lack of insulin produced by the pancreas or it is when the cells do not respond to the insulin produced, it is also according to the type of diabetes that the cause may be different from others. There are two types of diabetes, type 1 and 2. Type 2 diabetes is mostly common found in adults, to reduce the glucose level, the subject can change diet or have a lot of exercise or if that doesn’t workRead MoreStem Cell Therapy Essay1036 Words   |  5 Pagesincreasing at accelerated pace. A lot of research areas had emerged for that purpose including one of the most fascinating and highly active areas at present, stem cells therapies. Due to self-renewal property and differentiation capability of stem cell, it becomes a new hope in modern treatment. The first successful case of stem cell therapy in human was reported in 1959. Bone marrow restorations were observed in leukemia patients who received total body irradiation subsequent by intravenous injectionRead MoreStem Cell Gene Therapy Essay903 Words   |  4 PagesIn recent years, hematopoietic stem cell gene therapy (HSC GT) has emerged as an innovative strategy to cure several primary immunodeficiency disorders such as Severe Combined Immunodeficiency (SCID) and Wiskott-Aldrich Syndrome (WAS). The Wiskott-Aldrich syndrome is an â€Å"X-linked, complex primary immunodeficiency disorder caused by mutations in the WAS gene and is characterized by recurrent infections, thrombocytopenia, eczema, autoimmunity and an increased risk of lymphoma† (1). Severe WAS can leadRead MoreStem Cell Therapy Project Essay examples678 Words   |  3 PagesINVESTIGATING BIOTECHNOLOGY Stem Cell Therapy Project Stem Cell Therapy Definition Stem cell therapy is the use of a person’s own stem cells to treat or prevent a disease or condition. A form of stem cell therapy that has been used for many years is bone marrow transplants. Application 1. Medical Uses Bone-marrow has been used to treat patients with cancers such as leukemia and lymphoma. This is the most common form of stem cell therapy and has been used for over 30 years. ChemotherapyRead MoreStem Cell Therapy for Heart Failure Essay918 Words   |  4 Pagesdeveloped the uses of stem cell therapy to heal the damage caused by heart attack. This therapy is still at the trial stage where they examined the safety of treating scars and cardiac tissue damage using stem cells. Stem Cell Therapy for Heart Failure This therapy is said to be a promising therapy for heart failure patients as stem cell therapy uses stem cell derived from the patient and thereby it is not at risk of being rejected from the body immune system. Several stem cell therapy researches haveRead MoreParkinson s Disease As A Medical Condition1437 Words   |  6 Pagesliterature. It wasn’t until 1817 that a London doctor, named James Parkinson, wrote a detailed medical essay on this disease. This essay established Parkinson’s disease as a recognized medical condition. He based the essay off of six cases he had observed previously and hoped that it would encourage others to study the disease. No such research was performed until finally, sixty years after Parkinson’s essay was published, a French neurologist named Jean Charcot studied the disease and was the first toRead MoreStem Cells Essay1699 Words   |  7 Pageshas provided us with a hope for these diseases. This essay will address the issue of co ntroversial research in stem cells. This technology offers hope to millions who are victims of a multitude of diseases and disorders. It can be used to regrow limbs, create organs, attack genetic diseases, treat malfunctioning bladders, etc. However, this same technology is also one of the most controversial debates in science today. If you type â€Å"stem cells research† into your Google search bar, you will most likelyRead MoreResearch Essay : Stem Cell Research961 Words   |  4 PagesResearch Essay Erica Ford In recent years, there has been a lot more talk about stem cell research than ever before. The idea of stem cells arose in the 1960 s, with the first successful bone marrow transplant in 1968. Now, stem cell research is a widely known topic in biotechnology and shows a substantial amount of scientific promise. The future of stem cell research and the impact it could have follows with many questions on people s minds, as well the simple curiosity of what stem cellsRead More Stem Cells: What How and Why? Essay1130 Words   |  5 Pages Stem Cells: What, How and Why? Stem cells are infinitely valuable when considering their potential applications in the medical profession. While current legislative restrictions have halted the development of new ?stem cell lines? to any agency or company that receives any form of governmental grants, there is no question that the medical profession is standing at the brink of a new era of technological advancements in healthcare and research. Stem cells are valuable due to the fact that theyRead MoreThe Debate Over Embryonic Stem Cell Research852 Words   |  4 Pagesknowledge of stem cell research has already created the ability for doctors to print a functional organ just as easily as people can print a persuasive research essay. With great medical advancements comes great controversy. The main way researchers have been studying stem cells is by harvesting undifferentiated embryonic stem cells. Those who oppose embryonic stem cell research claim that stem cell harvesting damages and kills the un-born embryo; however, because of advancements in the stem cell harvesting

Opioid Substitution Treatment Barriers Health And Social Care Essay Free Essays

ISSUES. Opioid permutation intervention is internationally recognised as the most effectual intercession available to handle opioid dependance. There is concern that capacity at public clinics and pharmaceuticss is deficient to run into high demand, ensuing in a cohort of opioid-dependent patients left untreated. We will write a custom essay sample on Opioid Substitution Treatment Barriers Health And Social Care Essay or any similar topic only for you Order Now Research has focussed on pharmaceutics barriers to OST bringing but small is known about the public clinic sector. APPROACH. A narrative reappraisal was conducted by thorough scrutiny of relevant literature in electronic databases ; Medline, CINAHL and Cochrane. Cardinal FINDINGS. Despite the enlargement of OST and vacancies in pharmaceuticss, some opioid-dependent patients continue to confront barriers that block entree to intervention. These barriers are varied and multi-faceted. For the patient, stigma and a compulsory dispensing fee are important deterrences to pharmacy dosing. For the druggist, negative behaviors associated with OST patients such as debt, larceny and aggressive behavior and full capacity are grounds that impede proviso of OST. In public clinics, the backlog of stable patients non being transferred to pharmacy dosing is a suspected barrier that has non been extensively investigated. IMPLICATIONS. Research has explored pharmaceutics and patient barriers to OST entree but less is known about the public clinic barriers. More research is warranted into public clinics to clarify possible barriers of all grades of the OST system. CONCLUSION. This reappraisal emphasises the dearth of research into OST bringing in public clinics. Further probe into the processs of OST in clinics is necessary and should concentrate on patient appraisal, referral and direction. Keywords: opioid permutation intervention, pharmaceutics, clinic Word count: 246 Researching barriers to opioid permutation intervention in pharmaceuticss and public clinics Introduction Opioid dependance carries a scope of important inauspicious wellness, economic and societal jobs to the person and wider community, including the hazard of overdose, the spread of infective diseases ( HIV/AIDS, hepatitis B and C ) , psychological jobs, drug-related offense, wellness impairment and household break [ 1, 2 ] . Opioid permutation intervention ( OST ) is internationally recognised as the most good and cost-efficient pharmacological intercession available for the intervention of opioid dependance [ 3, 4 ] . In response to an addition in the Australian population of heroin-dependent users in the 1990s [ 5, 6 ] the authorities introduced OST as a injury minimization scheme to understate these inauspicious effects [ 7 ] . Since so OST bringing has steadily increased under the National Pharmacotherapy Policy and National Drug Strategy [ 7, 8 ] . The figure of patients has risen in surplus of 2,000 clients per twelvemonth since 2007 and at the clip of authorship, there are pres ently over 46, 000 clients having intervention in Australia entirely [ 8 ] . In Australia, OST involves supervised day-to-day dosing of one of three long-acting opioid replacing medical specialties ( dolophine hydrochloride, buprenorphine or buprenorphine/naloxone ) . Most new patients are initiated into intervention by the doctor at a public clinic under the supervising of a nurse or instance director. In this scene they have entree to single instance direction, reding and specialist medical support at no charge. Once they become stabilised on intervention, patients are encouraged to reassign their dosing to a community pharmaceutics [ 2 ] , thereby emancipating their dosing topographic point at the public clinic for a new patient. There is a concern that this tract is non every bit smooth as it appears. As at June 2008, an estimated 41,000 opioid dependent people in the community were still unable to entree intervention and the job is declining [ 9 ] . Confusing the job is the fact that there is no bing agencies of measuring the precise demand for intervention and no systematic monitoring of waiting times in the pharmacotherapy system [ 9 ] . Proposed accounts for this issue are varied and multi-faceted. It is believed the system capacity at both the populace clinics and the community pharmaceutics degrees may non be sufficient to suit the high demand for OST, therefore the ground why an estimated 50 % heroin-users are non in intervention. Previous surveies have investigated the pharmaceutics barriers to OST but at that place appears to be a deficiency of research into the drug and intoxicant clinics [ 10, 11 ] . This reappraisal aims to research the literature refering to OST in Australia. In peculiar the reappraisal will look into the grounds for the â€Å" unmet demand † [ 9 ] of opioid dependant patients necessitating these services and the bing barriers to the proviso, entree and consumption of OST faced by both patients and healthcare suppliers. Method A narrative literature reappraisal was conducted by thorough scrutiny of the literature in 3 electronic databases Medline, CINAHL and Cochrane. The undermentioned keywords and phrases were searched: â€Å" opiate ( opioid ) permutation ( replacing ) intervention ( therapy ) † , â€Å" referral † , â€Å" dolophine hydrochloride † , â€Å" buprenorphine † , â€Å" pharmaceutics † , â€Å" drug and intoxicant clinic † , â€Å" drug wellness clinic † and â€Å" harm minimization † . The mentions of relevant literature were besides searched. Documents were eligible for inclusion if they were written in English and published between the old ages 2000 and 2012. Documents were excluded if they chiefly focused on detoxification plans, naltrexone intervention, dolophine hydrochloride for hurting alleviation or if they pertained to patients other than big opioid-dependent patients. A comprehensive hunt of Australian cyberspace resources was besides conducted. The primary sites were Australian national and province authorities wellness policy and statistics sites ( hypertext transfer protocol: //www.druginfo.nsw.gov.au/ , hypertext transfer protocol: //www.aihw.gov.au/ , hypertext transfer protocol: //www.health.nsw.gov.au/ , hypertext transfer protocol: //www.nhmrc.gov.au ) and the UNSW National Drug A ; Alcohol Research Centre ( NDARC ) . RESULTS AND DISCUSSION: Several surveies have shown OST to be associated with benefits including reduced illicit opioid usage, lower associated offense rates and improved wellness results [ 3, 12, 13 ] . It has besides been demonstrated to be more extremely cost-efficient than detoxification or rehabilitation [ 4 ] . In response to increasing demand, the figure of dosing sites in Australia has increased from 2,081 ( 2005-06 ) to 2,200 ( 2009-10 ) with the major addition being in the figure of new pharmaceuticss taking to offer OST services [ 8 ] . Community pharmaceuticss are the chief suppliers of OST in Australia, accounting for 43 % of OST patients in NSW. This is in line with other states such as the UK, France, Germany and New Zealand where pharmaceutics is emerging as a head of OST proviso [ 14-16 ] . Although pharmacy proviso of OST has expanded, there are still people who can non entree these dosing sites, restricted by certain barriers. The lone solid grounds of these people is on waiting lists, but presently in Australia there is no official demand to supervise waiting lists or capacity [ 9, 17-19 ] . Factors explicating the inability of OST plans to run into current demand are multifaceted and interconnected and scope from deficient figure of intervention topographic points depending on location to barriers faced by patients in accessing OST such as rural location or restricted dosing hours. Much research has focussed on the challenges faced by suppliers of OST services, viz. community pharmaceuticss, GPs and public clinics. OST in community pharmaceutics Community pharmaceutics histories for 43 % of OST patients in NSW. Most surveies on OST proviso are survey-based. In a study of NSW public clinic patients, 80 % of participants preferable pharmaceutics dosing over the clinic [ 20 ] . Benefits of pharmaceutics that have been cited in patient studies include greater community integrating, a more stable dosing environment, flexible dosing hours, less travel clip and cost ( the patient may be referred to a pharmaceutics closer to their reference ) and the chance for regular takeout doses [ 20-22 ] . Takeouts are extremely valued by opioid dependent patients as they facilitate the standardization of life [ 21 ] . Patients can devour their dosage unsupervised and the decreased frequence of dosing attending allows clients to prosecute employment and instruction chances and fulfil household duties. Sing they are merely routinely given to stable patients in community pharmaceuticss and non by and large in public clinics, takeouts are a major inducement to pharmaceutics dosing. Although demand and patient penchant for pharmaceutics dosing is high, patients may still confront barriers that deter them from come ining into pharmaceutics intervention. Stigma Whilst patients on OST reported high degrees of satisfaction, a common issue in dosing sites was the presence of negative staff opinion and stigma [ 10, 21, 22 ] . When Deering et Al. ( 2011 ) asked New Zealand OST patients how intervention could be improved, an overpowering bulk identified ‘better intervention by staff ‘ [ 10 ] . The position that staff behavior could be improved was supported in a study by Kehoe et Al. ( 2004 ) nevertheless contrastingly 80 % of respondents besides reported that staff intervention was satisfactory or first-class [ 21 ] . This disagreement suggests that whilst patients were overall satisfied with staff intervention, they still felt the demand for betterment. Financial load Another common hindrance to OST identified in the literature is the fiscal load of intervention faced by patients [ 11, 20, 22, 23 ] . Whilst intervention costs in NSW public clinics are to the full subsidised by the province authorities, pharmaceutics dosing incurs a hebdomadal dispensing fee runing from about $ 30- $ 35 [ 22 ] . In one survey, 32 % of public clinic patients surveyed claimed they could non afford the pharmaceutics distributing fees perchance explicating their involuntariness to reassign to pharmacy [ 20 ] . The balance were merely able to pay an mean $ 10 a hebdomad, an sum well lower than $ 33.56, the average hebdomadal dispensing fee reported by Lea et al [ 22 ] . The fact that 23 % pharmaceutics clients owed the pharmaceutics money for dosing [ 22 ] confirms that a significant figure of OST clients struggle to afford pharmaceutics distributing fees. The theoretical account used in Canberra in which 50 % of the distributing fee is subsidised, [ 24 ] is intended to ease the pecuniary load and act as an added inducement for intervention keeping or entryway. No surveies have yet evaluated the consequence of lower fees on patient keeping times. From the druggist perspective client debt likewise serves as a deterrence against the bringing of OST or uptake of new patients. Other jobs related to behavioral disinhibition, aggression, larceny and the negative impact on concern and other clients have all been identified as grounds impacting druggists ‘ proviso of OST [ 25, 26 ] . In contrast to pharmacist concerns, one survey in the UK interviewed pharmaceutics clients and found the bulk to be overall supportive of pharmaceuticss presenting drug user services [ 14 ] , with the specification that privateness was necessary. The demand for equal privateness is in line with OST patient positions [ 22 ] . However qualitative informations was sourced from interviews which may be skewed by interviewee disposition to give socially desirable replies. Role of the GP prescriber Another common job experienced by community druggists is the trouble reaching prescribers and the prescribing of takeout doses to unstable patients [ 26 ] . Pharmacists identified the hazard of recreation of takeout doses and hapless appraisal of stableness as issues that required improved interprofessional coaction with prescribers. Interestingly in one survey a bulk of druggists agreed that prescriber communicating was equal, nevertheless little sample size and the rural location which tends to further closer interprofessional relationships may be accountable [ 27 ] . Winstock et Al. ( 2010 ) recommends the public-service corporation of standardized resources such as the NSW Department of Health ‘Patient Journey Kits ‘ to steer multidisciplinary attention of OST patients [ 26, 28 ] . Another facet lending to system capacity is the reduced supply of prescribers for OST. GPs are frequently the first point of contact for opioid-dependent people. They are required to set about extra preparation to go commissioned opioid pharmacotherapy prescribers [ 29 ] . GPs play an intrinsic function in the initial showing, appraisal and on-going feedback and monitoring of OST clients. The issue lies in the ripening work force and the retirement of commissioned prescribers, thereby cut downing intervention entree [ 17 ] . Public clinics are the lone prescribing option but considerable barriers including full system capacity and the deficiency of motion of stable patients out of clinics into pharmaceuticss besides limit the public clinics ability to suit excess patients. Unexplained vacancies Despite grounds of an â€Å" unmet demand † [ 9 ] , a survey conducted by the National Drug and Alcohol Research Centre ( NDARC ) found that more than half of OST-providing pharmaceuticss reported an norm of 7 vacancies to dose extra patients. Data extrapolation of to all NSW pharmaceuticss registered to present OST suggests that there are about 3000 vacant dosing topographic points across NSW. Whilst a 3rd of pharmaceuticss in the survey were runing at full capacity, some pharmaceuticss reported functioning no clients [ 18 ] . This spectrum of clients across registered pharmaceuticss and the being of current vacancies exemplify the underutilisation of community pharmaceutics dosing topographic points. However the fact that these vacancies may non ever be located where the demand is highest has to be taken into consideration. For illustration patient entree to intervention in rural locations is frequently restricted due to limited pharmaceutics Numberss and longer going distan ces [ 25 ] . From the literature, it appears NSW pharmaceuticss have the capacity to increase consumption of clients, with a possible 70 % of pharmaceuticss capable but non willing to supply OST services. Factors identified that would promote druggists to increase client Numberss include the stableness of the patient, higher fiscal additions per client and the option to instantly return unstable patients to public clinics [ 18 ] . However some public clinics expressed concern about taking back unstable patients, proposing there was no warrant of available dosing capacity, one time a new patient had been inducted [ 18 ] . OST in public clinics Entree to OST is determined by both the handiness of pharmaceuticss supplying OST every bit good as the capacity of public clinics to take on extra clients [ 19, 26 ] . However harmonizing to an expansive NSW state-wide study on OST by Winstock et Al. ( 2008 ) , there appears to be an underutilisation of available pharmaceutics dosing sites and limited capacity in public clinics [ 19 ] . Whilst the bulk of literature has focussed on pharmaceutics proviso of OST, relatively less research has been conducted into the public clinic grade of the OST system despite representing 19 % of dosing patients in NSW [ 8 ] . Public clinics have become an increasing country of involvement driven by studies that the motion of stable patients through the clinics out to community pharmaceuticss appears to be dead [ 17, 19 ] . This is ensuing in a backlog of patients barricading new patients from accessing intervention at the clinics. The proportion of stable patients transferred from the clinics to pharmaceuticss is estimated to be really low at 3-15 % a month [ 18 ] . Surveyed patients have cited a reluctance or inability to afford a dispensing fee and feeling dying about reassigning [ 20 ] as grounds against transportation. Precedence groups Intensifying the limited capacity of public clinics is the duty of supplying priority entree of vacancies to groups that meet standards stipulated under NSW Health directives [ 2, 7 ] . Cohorts include released captives, pregnant adult females, people with HIV, hepatitis B bearers and those on a recreation plan as ordered by the tribunal. [ 19 ] Similarly clients that show hazardous forms of illicit substance maltreatment such as those with mental unwellness and intoxicant dependance, or those that exhibit aggressive or antisocial behaviors are better managed at the public clinic instead than at a pharmaceutics. As a consequence many patients who do non run into ‘priority ‘ position are forced to wait. Obviously there is a demand to increase the efficient transportation rate of patients out to pharmaceuticss to do infinite for these clients. As antecedently mentioned, there is no consistent systematic process or set guidelines to help clinicians in covering with these iss ues and as of yet, no research has been conducted on their response to pull offing these issues. A 2008 SWAT study of NSW public clinics reported that when unable to offer immediate intervention, clinics either provided injury decrease advice referred to another public clinic, a private clinic or a GP, or offered detoxification. The assortment of actions and the effectivity of each have non been assessed and look to be decided upon at the discretion of the presiding OST practician at the clinic. Recommendations by the SWAT squad include developing a standardised response when a clinic can non offer a intervention topographic point to a client, and systematic monitoring of capacity to explicate more timely intervention in the hereafter [ 19 ] . Stability appraisal and referral processs An obstruction inherent to the pharmacotherapy system is the clinical appraisal of patient stableness and referral process. The triage function of stableness appraisal is usually coordinated by Nursing Unit of measurement Managers ( NUMs ) or a cardinal stakeholder in the public clinic and involves reexamining patient dosing history and behavior and placing those suited for transportation [ 30 ] . Currently no surveies into the clinical function or preparation of NUMs in OST proviso have been conducted. Soon determinations are guided by clinical opinion. The lone available counsel is limited to authorities policy, instead than scientific grounds and no standardized guidelines exist [ 30 ] . Whilst there are over 300 hazard appraisal instruments available to mensurate results of patients in drug and intoxicant intervention, no individual standardised attack has been nationally adopted or endorsed for OST [ 30 ] . A survey by Winstock et Al. ( 2009 ) found that execution of a province broad preparation plan improved client stableness appraisal with 25 % of staff increasing the figure of clients transferred out to community pharmaceutics [ 31 ] . However the objectiveness of this survey was affected as the method involved clinicians self-reporting cognition and accomplishments prior to and after preparation. However the survey provides preliminary grounds that acceptance of standardized appraisal processes increases the transparence of clinical determinations and can better entree to O ST [ 19, 31 ] . As above-named there appears to be underutilisation of community pharmaceutics OST services with some dosing at full capacity, whilst at the other terminal of the spectrum, some pharmaceuticss serve no patients. The bulk of pharmaceuticss reported vacancies. Whilst 75 % of clinics reportedly monitored available capacity within local pharmaceuticss, it is possible that the remainder are directing clients to overfilled dosing sites [ 18 ] . No formal survey has as of yet explored how clients refer and allocate patients to pharmaceuticss and how pharmaceuticss are selected. Decision From the reappraisal of the literature, there is grounds to propose that the current opioid permutation intervention capacity may non be sufficient to run into demand for intervention. Several barriers have been identified that restrict patient entree to intervention. Pharmacy barriers include the minority of community pharmaceuticss that opt in to present dosing, pharmacist reluctance to take on new patients due to perceived associated negative behaviors and old experiences and patient involuntariness or inability to pay the dispensing fee. The deficiency of prescribers is another aspect contributing to the decreased entree to available intervention. An country of involvement is the part of the public clinic grade of the OST system, nevertheless there is an evident dearth of research conducted into the direction of OST entree in public clinics. The dead flow of stable patients reassigning dosing from the public clinics to community pharmaceuticss is suspected to be impacting entree to intervention for new patients who do non run into precedence standards and are forced to wait. There is preliminary grounds to propose that a standardized attack to stability appraisal may ease stable patient transportation and liberate dosing sites in clinics for non-priority groups. Further research needs to be conducted into the stableness appraisal and referral processs of OST, the bing tools and processs and how effectual they will be in shuting the spread between demand and supply of OST. How to cite Opioid Substitution Treatment Barriers Health And Social Care Essay, Essay examples

The Influence and Impact on the Bio free essay sample

The Ecological systems theory was originated by the famous Urie Bronfenbrenner, who believed that children developed within a complex system of relationships affected by multiple levels of the environment (Berk, 2000). As we know the Bioecological Model system has four basic systems. Bronfenbrenner was one of the first people to embrace human development. He establishes this theory which influences many other social scientists to study human being and their environment. Through his study he acknowledges the importance of human being develop in which how children are raise. This system helps to recognizes that children develop from their family, school, home surrounding and society. In fact the ecological theory explains how the child environment affects how our children grow and develop. Although we as parents and even teachers seem to think that we know how our children grow, but as individuals do we fully understand what affect or enhance our children process of development. The first system that influences development is the Microsystems. The micro system refers to the child experiences with immediate interactions with others people. From the first part of the child life, the micro-system start within the home, involving only interactions with one or two people in the family. As the child continue to grow or age the micro-system start to get more complex, which involve more people in the child foe example, day-care center or attending school. Actually this part of the development includes things that a child may experience on a daily basis in his/her surrounding or environment. However, as the child constant interact with other; often determine how the child will grow and development. Furthermore, the more the parents, caregiver or individual encourage or nurture the relationship in the micro-system, the better the child will grow up. The micro-system explain that a lot of relationships one establish in this system, the more bidirectional influences on the child development, both toward and away from the child like the parents as well as the parents influence on the child. The second system is Mesosystem, which consist of an upper stage that connects between the different of the child or individual micro-system. Actually this explain the experiences between teachers and peers, parents and teachers, school and church, family with, peers, etc. Often in this structure children who does not have a strong relationship or even a connection, can feel rejected by their parents and could experiences difficulty developing relationships with others individuals The exosystems is the third structure of the system, which refers to the community level influences including fairly established norm, standards and social work (Gregson, 2001), it also include the workplace, and family members. For instance, in today economy where there are fewer jobs and because parents to get laid off can cause affect on the child, due to lower income in life style changes. This stage of Bronfenbrenner theory deals with all aspects or changes the child development that comes with limitations that acts on any part of the system. The fourth and last level is the Macro system, which describes the culture that the child lives in. This part of the system is the largest and most influences set of things and individuals on the child development. Urie, macro-system consists of the relationships between cultural values, norms government rights, beliefs, etc. The system influences the children or individual directly, but can also cause less motivation in the child setting, for instance capitalism ands socialism and religion whether it Christian, full gospel etc. He stated that â€Å"resources hazards, life styles, opportunity structures, life course options and patterns of social interchange† (Bronfenbrenner, 1993). Most of all the Bioecological Model of Human Development is the views that an individual develop within a complex system of relationships affected by multiple structures of the surrounding and environment. Bronfenbrenner model system is differing from each other in various ways. Take the micro-system it tell us that children are influences by neighborhood, school, family or the child care center, which carry a strong impact on the development. Study shows in this level how the child behavior affects the parents and the parents affect the child. He call these bidirectional influences and he conduct a study showing other scientists and teachers how they exist in the environment. Furthermore, the micro-system, bidirectional can be proven to have the greatest impact or influences on the child development. The mesosystem plays it part in the model system too. It differs by showing the connection between the children in the micro-system. These connections can be between the teacher and parent or the community and the church. The exosystem structure is differs, because it describe the larger connection within the system, which say that the child does not operation or function directly. However, it goes to explain that the development to some what interact with the micro-system. A noted before this can come from the parents, their workplace, the media and etc. The macro-system is differs, because it deals with the culture, economy, etc. This level enhances or shapes the child growth. According to research Bronfenbrenner create this system just to understand the mid and growth of an individual development. He was the leading researcher to review family political and economy structure influences the development of child into adulthood. Through his theory scientist, teachers, and individual can place emphasis on the nature and nurture common in children development. The Ecological Model System Theory tend to experiment the differences in the child knowledge, competencies and development through guidance and structure in the environment in which we live. Understanding the influences of these systems is the key concept of understanding how a child develops and points out leading concerns that can actually lead to failure. As a parents demands more work hours and often make work their first goals has been proven to impact the child development, because it reflect to less time to interact with the child. According to Bronfenbrenner this is a major destructive on the child. He proved that the micro-system break down the child growth or development causes them to have no interactions to discover difference part of their environment or society. In conducting this research it shows that a primary interaction or relationships are those that last a life span with the parents and certainly cannot be redeem with others. The Bioecological Model of Human Development explain that the greatest interaction or relationship is the best way for a child to development and parents or teachers need to support these interactions by creating an safe environment and nurtures families. According to research there are many outside influences that impact a child development. Actually a child behavior can affect by many factors emotional, social, environmental and biological. For example, social influence affects the child development by being or exposed to peers on a daily basis, which causes the child to be influence by them. By the child wanting to be or feel accepted among their peers the impact can cause or damage the way the child act in the home. However, Piaget says that social development â€Å"peer interactions are crucial to the child’s construction of social and moral feeling, values, and social and intellectual competence† (Piaget, 1932/1965). Another outside impact is emotional development. A child with emotional depression issues can affect the environment of the home as well as the school. Unfortunately, each day in school environment teachers are dealing with numerous of children with social and emotional problems. As parents are seeking advance help to face and deal with these issues, some schools counsels are becoming the first solution to those troubling problems. Due to the study it is better to unite with the family, school and community to understand the issues that lead to the child or individual social or emotional problems. Indeed with these issues or problems learning Bronfenbrenner systems and understanding the concepts of how it works, we can look for alternative sources within the systems to resolve these problems. Furthermore, a child home environment can impact a child behavior positively or negatively. His study show where there is domestic violence or disagreement in the home can cause harmful reactions that lead to a lack of security for the child. Even an unsafe school environment can have a negative affect on the child behavior too. One main concern that the school teachers are facing in the school system today is bullying that possession a huge impact on the child life. An example for the micro-system would be parents affect by the child behavior as well as the child can be effect or drawn forth by the parents genes or traits. This approach can be from an bidirectional experience in the environment. The micro-system is the inner layer of the environment made up on relationships and interactions in the child society or surrounding. The next example is mesosystem, which is the link and structure that connect between the micro-system. This connection can be between the knowledge or academic experiences in the environment, classroom or lifestyle. The exosystem level or structures give example of the primary family, parent workplace, media, etc. Although they may not have physical contact with it, the organization affects the child development in all aspects. The last example is the macro-system, which is the outer layer of the bioecological model system. The macro-system often explain how values, laws and culture in the child development. Mainly it requires high expectation for the child and parents workplace. With this structure children with a strong belief or religion background will be strongly influences by the parents. According to research conduct this model is impact by the whole systems, which can be indirect, but still can hold a powerful influence on the individual. The child is the center of attention in this theory. The systems of model acknowledge that a child can be affected by the setting of their surrounding. From the research so far, one can conclude that a child family setting is very important, because this is where the child spends a large amount of their time. Other influences that are important to the systems structures are teachers, community, and peers. A child’s development as we all know is determined by the experiences in the home in the environment. By teaching the child appropriate ways to behave, talking and reading to them, and providing equipment and material, so they can interact with others has positive influences on the child and also help to enhance the development process. The negative affect of this theory is parents not spending enough time with the child and teachers who are not use this theory to enhance their teaching skills to advance their knowledge on how child body and mind development. Urie Bronfenbrenner, bioecological system simple break down all the things we need to know about how we development. This theory would be a great approach for teachers today to understand why our children are impact and influences by people, belief, values, community, church, government, school and family in our society. Unfortunately, teachers need to be aware of the differ factors that influences the child personality, just as well as they need to identify the behavior in the classroom. In conclusion, although we as parents and teachers seem to think that we know how children development, according to the bioecological model systems there more to child influences than just the home and schools environment. The key factor of this theory is to help children develop into adults, molding them for the future. As the theory focus on the outcome of wishing that children reach their goal. Scientists are constantly finding ways to improve and enhance the human development process. Bronfenbrenner design this systems to help understand children growth process, he emphasized that it is necessary to observe the child behavior and reaction in the community and society. In fact the systems allow researcher to discover some interesting points about why children hold positive and negative attitudes in life. The model systems deals with human development as a whole it language, cognitive, social, emotional, physical, and creative development.

The Effects Of HIV Mutations On The Immune System Essay Example For Students

The Effects Of HIV Mutations On The Immune System Essay INTRODUCTION The topic of this paper is the human immunodeficiency virus, HIV, and whether or not mutations undergone by the virus allow it to survive in the immune system. The cost of treating all persons with AIDS in 1993 in the United States was $7.8 billion, and it is estimated that 20,000 new cases of AIDS are reported every 3 months to the CDC. This question dealing with how HIV survives in the immune system is of critical importance, not only in the search for a cure for the virus and its inevitable syndrome, AIDS (Acquired Immunodeficiency Syndrome), but also so that over 500,000 Americans already infected with the virus could be saved. This is possible because if we know that HIV survives through mutations then we might be able to come up with a type of drug to retard these mutations allowing the immune system time to expunge it before the onset of AIDS. We will write a custom essay on The Effects Of HIV Mutations On The Immune System specifically for you for only $16.38 $13.9/page Order now BACKGROUND In order to be able to fully comprehend and analyze this question we must first ascertain what HIV is, how the body attempts to counter the effects of viruses in general, and how HIV infects the body. Definition HIV is the virus that causes AIDS. HIV is classified as a RNA Retrovirus. A retrovirus uses RNA templates to produce DNA. For example, within the core of HIV is a double molecule of ribonucleic acid, RNA. When the virus invades a cell, this genetic material is replicated in the form of DNA . But, in order to do so, HIV must first be able to produce a particular enzyme that can construct a DNA molecule using an RNA template. This enzyme, called RNA-directed DNA polymerase, is also referred to as reverse transcriptase because it reverses the normal cellular process of transcription. The DNA molecules produced by reverse transcription are then inserted into the genetic material of the host cell, where they are co-replicated with the hosts chromosomes; they are thereby distributed to all daughter cells during subsequent cell divisions. Then in one or more of these daughter cells, the virus produces RNA copies of its genetic material. These new HIV clones become covered with protein coats and leave the cell to find other host cells where they can repeat the life cycle. The Body Fights Back As viruses begin to invade the body, a few are consumed by macrophages, which seize their antigens and display them on their own surfaces. Among millions of helper T cells circulating in the bloodstream, a select few are programmed to read that antigen. Binding the macrophage, the T cell becomes activated. Once activated, helper T cells begin to multiply. They then stimulate the multiplication of those few killer T cells and B cells that are sensitive to the invading viruses. As the number of B cells increases, helper T cells signal them to start producing antibodies. Meanwhile, some of the viruses have entered cells of the body the only place they are able to replicate. Killer T cells will sacrifice these cells by chemically puncturing their membranes, letting the contents spill out, thus disrupting the viral replication cycle. Antibodies then neutralize the viruses by binding directly to their surfaces, preventing them from attacking other cells. Additionally, they precipitate chemical reactions that actually destroy the infected cells. As the infection is contained, suppresser T cells halt the entire range of immune responses, preventing them from spiraling out of control. Memory T and B cells are left in the blood and lymphatic system, ready to move quickly should the same virus once again invade the body. HIVs Life Cycle In the initial stage of HIV infection, the virus colonizes helper T cells, specifically CD4+ cells, and macrophages, while replicating itself relatively unnoticed. .u38db47f5f00574bc9f1453c4c2eec17c , .u38db47f5f00574bc9f1453c4c2eec17c .postImageUrl , .u38db47f5f00574bc9f1453c4c2eec17c .centered-text-area { min-height: 80px; position: relative; } .u38db47f5f00574bc9f1453c4c2eec17c , .u38db47f5f00574bc9f1453c4c2eec17c:hover , .u38db47f5f00574bc9f1453c4c2eec17c:visited , .u38db47f5f00574bc9f1453c4c2eec17c:active { border:0!important; } .u38db47f5f00574bc9f1453c4c2eec17c .clearfix:after { content: ""; display: table; clear: both; } .u38db47f5f00574bc9f1453c4c2eec17c { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .u38db47f5f00574bc9f1453c4c2eec17c:active , .u38db47f5f00574bc9f1453c4c2eec17c:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .u38db47f5f00574bc9f1453c4c2eec17c .centered-text-area { width: 100%; position: relative ; } .u38db47f5f00574bc9f1453c4c2eec17c .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .u38db47f5f00574bc9f1453c4c2eec17c .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .u38db47f5f00574bc9f1453c4c2eec17c .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .u38db47f5f00574bc9f1453c4c2eec17c:hover .ctaButton { background-color: #34495E!important; } .u38db47f5f00574bc9f1453c4c2eec17c .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .u38db47f5f00574bc9f1453c4c2eec17c .u38db47f5f00574bc9f1453c4c2eec17c-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .u38db47f5f00574bc9f1453c4c2eec17c:after { content: ""; display: block; clear: both; } READ: Ethical Hackers Essay As the amount of the virus soars, the number of helper cells falls; macrophages die as well. The infected T cells perish as thousands of new viral particles erupt from the cell membrane. Soon, though, cytotoxic T and B lymphocytes kill many virus-infected cells and viral particles. These effects limit viral growth and allow the body an opportunity to temporarily restore its supply of helper cells to almost normal concentrations. It is at this time the virus enters its second stage. Throughout this second phase the immune system functions well, and the net concentration of measurable virus remains relatively low. But after a period of time, the viral level rises gradually, in parallel with a decline in the helper population. These helper T and B . The Effects Of HIV Mutations On The Immune System Essay Example For Students The Effects Of HIV Mutations On The Immune System Essay INTRODUCTION The topic of this paper is the human immunodeficiency virus, HIV, and whether or not mutations undergone by the virus allow it to survive in the immune system. The cost of treating all persons with AIDS in 1993 in the United States was $7.8 billion, and it is estimated that 20,000 new cases of AIDS are reported every 3 months to the CDC. This question dealing with how HIV survives in the immune system is of critical importance, not only in the search for a cure for the virus and its inevitable syndrome, AIDS (Acquired Immunodeficiency Syndrome), but also so that over 500,000 Americans already infected with the virus could be saved. This is possible because if we know that HIV survives through mutations then we might be able to come up with a type of drug to retard these mutations allowing the immune system time to expunge it before the onset of AIDS. We will write a custom essay on The Effects Of HIV Mutations On The Immune System specifically for you for only $16.38 $13.9/page Order now BACKGROUND In order to be able to fully comprehend and analyze this question we must first ascertain what HIV is, how the body attempts to counter the effects of viruses in general, and how HIV infects the body. Definition HIV is the virus that causes AIDS. HIV is classified as a RNA Retrovirus. A retrovirus uses RNA templates to produce DNA. For example, within the core of HIV is a double molecule of ribonucleic acid, RNA. When the virus invades a cell, this genetic material is replicated in the form of DNA . But, in order to do so, HIV must first be able to produce a particular enzyme that can construct a DNA molecule using an RNA template. This enzyme, called RNA-directed DNA polymerase, is also referred to as reverse transcriptase because it reverses the normal cellular process of transcription. The DNA molecules produced by reverse transcription are then inserted into the genetic material of the host cell, where they are co-replicated with the hosts chromosomes; they are thereby distributed to all daughter cells during subsequent cell divisions. Then in one or more of these daughter cells, the virus produces RNA copies of its genetic material. These new HIV clones become covered with protein coats and leave the cell to find other host cells where they can repeat the life cycle. The Body Fights Back As viruses begin to invade the body, a few are consumed by macrophages, which seize their antigens and display them on their own surfaces. Among millions of helper T cells circulating in the bloodstream, a select few are programmed to read that antigen. Binding the macrophage, the T cell becomes activated. Once activated, helper T cells begin to multiply. They then stimulate the multiplication of those few killer T cells and B cells that are sensitive to the invading viruses. As the number of B cells increases, helper T cells signal them to start producing antibodies. Meanwhile, some of the viruses have entered cells of the body the only place they are able to replicate. Killer T cells will sacrifice these cells by chemically puncturing their membranes, letting the contents spill out, thus disrupting the viral replication cycle. Antibodies then neutralize the viruses by binding directly to their surfaces, preventing them from attacking other cells. Additionally, they precipitate chemical reactions that actually destroy the infected cells. As the infection is contained, suppresser T cells halt the entire range of immune responses, preventing them from spiraling out of control. Memory T and B cells are left in the blood and lymphatic system, ready to move quickly should the same virus once again invade the body. HIVs Life Cycle In the initial stage of HIV infection, the virus colonizes helper T cells, specifically CD4+ cells, and macrophages, while replicating itself relatively unnoticed. .u1784bd8f62e36d002e3ece86cd1528f9 , .u1784bd8f62e36d002e3ece86cd1528f9 .postImageUrl , .u1784bd8f62e36d002e3ece86cd1528f9 .centered-text-area { min-height: 80px; position: relative; } .u1784bd8f62e36d002e3ece86cd1528f9 , .u1784bd8f62e36d002e3ece86cd1528f9:hover , .u1784bd8f62e36d002e3ece86cd1528f9:visited , .u1784bd8f62e36d002e3ece86cd1528f9:active { border:0!important; } .u1784bd8f62e36d002e3ece86cd1528f9 .clearfix:after { content: ""; display: table; clear: both; } .u1784bd8f62e36d002e3ece86cd1528f9 { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .u1784bd8f62e36d002e3ece86cd1528f9:active , .u1784bd8f62e36d002e3ece86cd1528f9:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .u1784bd8f62e36d002e3ece86cd1528f9 .centered-text-area { width: 100%; position: relative ; } .u1784bd8f62e36d002e3ece86cd1528f9 .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .u1784bd8f62e36d002e3ece86cd1528f9 .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .u1784bd8f62e36d002e3ece86cd1528f9 .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .u1784bd8f62e36d002e3ece86cd1528f9:hover .ctaButton { background-color: #34495E!important; } .u1784bd8f62e36d002e3ece86cd1528f9 .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .u1784bd8f62e36d002e3ece86cd1528f9 .u1784bd8f62e36d002e3ece86cd1528f9-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .u1784bd8f62e36d002e3ece86cd1528f9:after { content: ""; display: block; clear: both; } READ: Civil Rights Movement Essay As the amount of the virus soars, the number of helper cells falls; macrophages die as well. The infected T cells perish as thousands of new viral particles erupt from the cell membrane. Soon, though, cytotoxic T and B lymphocytes kill many virus-infected cells and viral particles. These effects limit viral growth and allow the body an opportunity to temporarily restore its supply of helper cells to almost normal concentrations. It is at this time the virus enters its second stage. Throughout this second phase the immune system functions well, and the net concentration of measurable virus remains relatively low. But after a period of time, the viral level rises gradually, in parallel with a decline in the helper population. These helper T and B . The Effects Of HIV Mutations On The Immune System Essay Example For Students The Effects Of HIV Mutations On The Immune System Essay INTRODUCTION The topic of this paper is the human immunodeficiency virus, HIV, and whether or not mutations undergone by the virus allow it to survive in the immune system. The cost of treating all persons with AIDS in 1993 in the United States was $7.8 billion, and it is estimated that 20,000 new cases of AIDS are reported every 3 months to the CDC. This question dealing with how HIV survives in the immune system is of critical importance, not only in the search for a cure for the virus and its inevitable syndrome, AIDS (Acquired Immunodeficiency Syndrome), but also so that over 500,000 Americans already infected with the virus could be saved. This is possible because if we know that HIV survives through mutations then we might be able to come up with a type of drug to retard these mutations allowing the immune system time to expunge it before the onset of AIDS. We will write a custom essay on The Effects Of HIV Mutations On The Immune System specifically for you for only $16.38 $13.9/page Order now BACKGROUND In order to be able to fully comprehend and analyze this question we must first ascertain what HIV is, how the body attempts to counter the effects of viruses in general, and how HIV infects the body. Definition HIV is the virus that causes AIDS. HIV is classified as a RNA Retrovirus. A retrovirus uses RNA templates to produce DNA. For example, within the core of HIV is a double molecule of ribonucleic acid, RNA. When the virus invades a cell, this genetic material is replicated in the form of DNA . But, in order to do so, HIV must first be able to produce a particular enzyme that can construct a DNA molecule using an RNA template. This enzyme, called RNA-directed DNA polymerase, is also referred to as reverse transcriptase because it reverses the normal cellular process of transcription. The DNA molecules produced by reverse transcription are then inserted into the genetic material of the host cell, where they are co-replicated with the hosts chromosomes; they are thereby distributed to all daughter cells during subsequent cell divisions. Then in one or more of these daughter cells, the virus produces RNA copies of its genetic material. These new HIV clones become covered with protein coats and leave the cell to find other host cells where they can repeat the life cycle. The Body Fights Back As viruses begin to invade the body, a few are consumed by macrophages, which seize their antigens and display them on their own surfaces. Among millions of helper T cells circulating in the bloodstream, a select few are programmed to read that antigen. Binding the macrophage, the T cell becomes activated. Once activated, helper T cells begin to multiply. They then stimulate the multiplication of those few killer T cells and B cells that are sensitive to the invading viruses. As the number of B cells increases, helper T cells signal them to start producing antibodies. Meanwhile, some of the viruses have entered cells of the body the only place they are able to replicate. Killer T cells will sacrifice these cells by chemically puncturing their membranes, letting the contents spill out, thus disrupting the viral replication cycle. Antibodies then neutralize the viruses by binding directly to their surfaces, preventing them from attacking other cells. Additionally, they precipitate chemical reactions that actually destroy the infected cells. As the infection is contained, suppresser T cells halt the entire range of immune responses, preventing them from spiraling out of control. Memory T and B cells are left in the blood and lymphatic system, ready to move quickly should the same virus once again invade the body. HIVs Life Cycle In the initial stage of HIV infection, the virus colonizes helper T cells, specifically CD4+ cells, and macrophages, while replicating itself relatively unnoticed. .udacaaddb74868d06d5f759168fd8bd29 , .udacaaddb74868d06d5f759168fd8bd29 .postImageUrl , .udacaaddb74868d06d5f759168fd8bd29 .centered-text-area { min-height: 80px; position: relative; } .udacaaddb74868d06d5f759168fd8bd29 , .udacaaddb74868d06d5f759168fd8bd29:hover , .udacaaddb74868d06d5f759168fd8bd29:visited , .udacaaddb74868d06d5f759168fd8bd29:active { border:0!important; } .udacaaddb74868d06d5f759168fd8bd29 .clearfix:after { content: ""; display: table; clear: both; } .udacaaddb74868d06d5f759168fd8bd29 { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .udacaaddb74868d06d5f759168fd8bd29:active , .udacaaddb74868d06d5f759168fd8bd29:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .udacaaddb74868d06d5f759168fd8bd29 .centered-text-area { width: 100%; position: relative ; } .udacaaddb74868d06d5f759168fd8bd29 .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .udacaaddb74868d06d5f759168fd8bd29 .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .udacaaddb74868d06d5f759168fd8bd29 .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .udacaaddb74868d06d5f759168fd8bd29:hover .ctaButton { background-color: #34495E!important; } .udacaaddb74868d06d5f759168fd8bd29 .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .udacaaddb74868d06d5f759168fd8bd29 .udacaaddb74868d06d5f759168fd8bd29-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .udacaaddb74868d06d5f759168fd8bd29:after { content: ""; display: block; clear: both; } READ: Trials And Tribulations Of Charles Dickens ( His L Essay As the amount of the virus soars, the number of helper cells falls; macrophages die as well. The infected T cells perish as thousands of new viral particles erupt from the cell membrane. Soon, though, cytotoxic T and B lymphocytes kill many virus-infected cells and viral particles. These effects limit viral growth and allow the body an opportunity to temporarily restore its supply of helper cells to almost normal concentrations. It . The Effects of HIV Mutations on the Immune System Essay Example For Students The Effects of HIV Mutations on the Immune System Essay Science C.J. Stimson INTRODUCTION The topic of this paper is the human immunodeficiency virus, HIV, and whether or not mutations undergone by the virus allow it to survive in the immune system. The cost of treating all persons with AIDS in 1993 in the United States was $7.8 billion, and it is estimated that 20,000 new cases of AIDS are reported every 3 months to the CDC. This question dealing with how HIV survives in the immune system is of critical importance, not only in the search for a cure for the virus and its inevitable syndrome, AIDS (Acquired Immunodeficiency Syndrome), but also so that over 500,000 Americans already infected with the virus could be saved. This is possible because if we know that HIV survives through mutations then we might be able to come up with a type of drug to retard these mutations allowing the immune system time to expunge it before the onset of AIDS. BACKGROUND In order to be able to fully comprehend and analyze this question we must first ascertain what HIV is, how the body attempts to counter the effects of viruses in general, and how HIV infects the body. Definition HIV is the virus that causes AIDS. HIV is classified as a RNA Retrovirus. A retrovirus uses RNA templates to produce DNA. We will write a custom essay on The Effects of HIV Mutations on the Immune System specifically for you for only $16.38 $13.9/page Order now For example, within the core of HIV is a double molecule of ribonucleic acid, RNA. When the virus invades a cell, this genetic material is replicated in the form of DNA . But, in order to do so, HIV must first be able to produce a particular enzyme that can construct a DNA molecule using an RNA template. This enzyme, called RNA-directed DNA polymerase, is also referred to as reverse transcriptase because it reverses the normal cellular process of transcription. The DNA molecules produced by reverse transcription are then inserted into the genetic material of the host cell, where they are co-replicated with the hosts chromosomes; they are thereby distributed to all daughter cells during subsequent cell divisions. Then in one or more of these daughter cells, the virus produces RNA copies of its genetic material. These new HIV clones become covered with protein coats and leave the cell to find other host cells where they can repeat the life cycle. The Body Fights Back As viruses begin to invade the body, a few are consumed by macrophages, which seize their antigens and display them on their own surfaces. Among millions of helper T cells circulating in the bloodstream, a select few are programmed to read that antigen. Binding the macrophage, the T cell becomes activated. Once activated, helper T cells begin to multiply. They then stimulate the multiplication of those few killer T cells and B cells that are sensitive to the invading viruses. As the number of B cells increases, helper T cells signal them to start producing antibodies. Meanwhile, some of the viruses have entered cells of the body the only place they are able to replicate. Killer T cells will sacrifice these cells by chemically puncturing their membranes, letting the contents spill out, thus disrupting the viral replication cycle. Antibodies then neutralize the viruses by binding directly to their surfaces, preventing them from attacking other cells. Additionally, they precipitate chemical reactions that actually destroy the infected cells. As the infection is contained, suppresser T cells halt the entire range of immune responses, preventing them from spiraling out of control. Memory T and B cells are left in the blood and lymphatic system, ready to move quickly should the same virus once again invade the body. HIVs Life Cycle In the initial stage of HIV infection, the virus colonizes helper T cells, specifically CD4+ cells, and macrophages, while replicating itself relatively unnoticed. As the amount of the virus soars, the number of helper cells falls; macrophages die as well. The infected T cells perish as thousands of new viral particles erupt from the cell membrane. Soon, though, cytotoxic T and B lymphocytes kill many virus-infected cells and viral particles. These effects limit viral growth and allow the body an opportunity to temporarily restore its supply of helper cells to . The Effects Of HIV Mutations On The Immune System Essay Example For Students The Effects Of HIV Mutations On The Immune System Essay INTRODUCTION The topic of this paper is the human immunodeficiency virus, HIV, and whether or not mutations undergone by the virus allow it to survive in the immune system. The cost of treating all persons with AIDS in 1993 in the United States was $7.8 billion, and it is estimated that 20,000 new cases of AIDS are reported every 3 months to the CDC. This question dealing with how HIV survives in the immune system is of critical importance, not only in the search for a cure for the virus and its inevitable syndrome, AIDS (Acquired Immunodeficiency Syndrome), but also so that over 500,000 Americans already infected with the virus could be saved. This is possible because if we know that HIV survives through mutations then we might be able to come up with a type of drug to retard these mutations allowing the immune system time to expunge it before the onset of AIDS. We will write a custom essay on The Effects Of HIV Mutations On The Immune System specifically for you for only $16.38 $13.9/page Order now BACKGROUND In order to be able to fully comprehend and analyze this question we must first ascertain what HIV is, how the body attempts to counter the effects of viruses in general, and how HIV infects the body. Definition HIV is the virus that causes AIDS. HIV is classified as a RNA Retrovirus. A retrovirus uses RNA templates to produce DNA. For example, within the core of HIV is a double molecule of ribonucleic acid, RNA. When the virus invades a cell, this genetic material is replicated in the form of DNA . But, in order to do so, HIV must first be able to produce a particular enzyme that can construct a DNA molecule using an RNA template. This enzyme, called RNA-directed DNA polymerase, is also referred to as reverse transcriptase because it reverses the normal cellular process of transcription. The DNA molecules produced by reverse transcription are then inserted into the genetic material of the host cell, where they are co-replicated with the hosts chromosomes; they are thereby distributed to all daughter cells during subsequent cell divisions. Then in one or more of these daughter cells, the virus produces RNA copies of its genetic material. These new HIV clones become covered with protein coats and leave the cell to find other host cells where they can repeat the life cycle. The Body Fights Back As viruses begin to invade the body, a few are consumed by macrophages, which seize their antigens and display them on their own surfaces. Among millions of helper T cells circulating in the bloodstream, a select few are programmed to read that antigen. Binding the macrophage, the T cell becomes activated. Once activated, helper T cells begin to multiply. They then stimulate the multiplication of those few killer T cells and B cells that are sensitive to the invading viruses. As the number of B cells increases, helper T cells signal them to start producing antibodies. Meanwhile, some of the viruses have entered cells of the body the only place they are able to replicate. Killer T cells will sacrifice these cells by chemically puncturing their membranes, letting the contents spill out, thus disrupting the viral replication cycle. Antibodies then neutralize the viruses by binding directly to their surfaces, preventing them from attacking other cells. Additionally, they precipitate chemical reactions that actually destroy the infected cells. As the infection is contained, suppresser T cells halt the entire range of immune responses, preventing them from spiraling out of control. Memory T and B cells are left in the blood and lymphatic system, ready to move quickly should the same virus once again invade the body. HIVs Life Cycle In the initial stage of HIV infection, the virus colonizes helper T cells, specifically CD4+ cells, and macrophages, while replicating itself relatively unnoticed. .u3d0cca5b57aba049692fb4850ab2a85b , .u3d0cca5b57aba049692fb4850ab2a85b .postImageUrl , .u3d0cca5b57aba049692fb4850ab2a85b .centered-text-area { min-height: 80px; position: relative; } .u3d0cca5b57aba049692fb4850ab2a85b , .u3d0cca5b57aba049692fb4850ab2a85b:hover , .u3d0cca5b57aba049692fb4850ab2a85b:visited , .u3d0cca5b57aba049692fb4850ab2a85b:active { border:0!important; } .u3d0cca5b57aba049692fb4850ab2a85b .clearfix:after { content: ""; display: table; clear: both; } .u3d0cca5b57aba049692fb4850ab2a85b { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .u3d0cca5b57aba049692fb4850ab2a85b:active , .u3d0cca5b57aba049692fb4850ab2a85b:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .u3d0cca5b57aba049692fb4850ab2a85b .centered-text-area { width: 100%; position: relative ; } .u3d0cca5b57aba049692fb4850ab2a85b .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .u3d0cca5b57aba049692fb4850ab2a85b .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .u3d0cca5b57aba049692fb4850ab2a85b .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .u3d0cca5b57aba049692fb4850ab2a85b:hover .ctaButton { background-color: #34495E!important; } .u3d0cca5b57aba049692fb4850ab2a85b .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .u3d0cca5b57aba049692fb4850ab2a85b .u3d0cca5b57aba049692fb4850ab2a85b-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .u3d0cca5b57aba049692fb4850ab2a85b:after { content: ""; display: block; clear: both; } READ: Analysis Of The Movie ' The Pursuit Of Happiness ' Essay As the amount of the virus soars, the number of helper cells falls; macrophages die as well. The infected T cells perish as thousands of new viral particles erupt from the cell membrane. Soon, though, cytotoxic T and B lymphocytes kill many virus-infected cells and viral particles. These effects limit viral growth and allow the body an opportunity to temporarily restore its supply of helper cells to almost normal concentrations. It is at this time the virus enters its second stage. Throughout this second phase the immune system functions well, and the net concentration of measurable virus remains relatively low. But after a period of time, the viral level rises gradually, in parallel with a decline in the helper population. These helper T and B lymphocytes are not lost because the bodys ability to produce new helper . The Effects Of HIV Mutations On The Immune System Essay Example For Students The Effects Of HIV Mutations On The Immune System Essay INTRODUCTION The topic of this paper is the human immunodeficiency virus, HIV, and whether or not mutations undergone by the virus allow it to survive in the immune system. The cost of treating all persons with AIDS in 1993 in the United States was $7.8 billion, and it is estimated that 20,000 new cases of AIDS are reported every 3 months to the CDC. This question dealing with how HIV survives in the immune system is of critical importance, not only in the search for a cure for the virus and its inevitable syndrome, AIDS (Acquired Immunodeficiency Syndrome), but also so that over 500,000 Americans already infected with the virus could be saved. This is possible because if we know that HIV survives through mutations then we might be able to come up with a type of drug to retard these mutations allowing the immune system time to expunge it before the onset of AIDS. We will write a custom essay on The Effects Of HIV Mutations On The Immune System specifically for you for only $16.38 $13.9/page Order now BACKGROUND In order to be able to fully comprehend and analyze this question we must first ascertain what HIV is, how the body attempts to counter the effects of viruses in general, and how HIV infects the body. Definition HIV is the virus that causes AIDS. HIV is classified as a RNA Retrovirus. A retrovirus uses RNA templates to produce DNA. For example, within the core of HIV is a double molecule of ribonucleic acid, RNA. When the virus invades a cell, this genetic material is replicated in the form of DNA . But, in order to do so, HIV must first be able to produce a particular enzyme that can construct a DNA molecule using an RNA template. This enzyme, called RNA-directed DNA polymerase, is also referred to as reverse transcriptase because it reverses the normal cellular process of transcription. The DNA molecules produced by reverse transcription are then inserted into the genetic material of the host cell, where they are co-replicated with the hosts chromosomes; they are thereby distributed to all daughter cells during subsequent cell divisions. Then in one or more of these daughter cells, the virus produces RNA copies of its genetic material. These new HIV clones become covered with protein coats and leave the cell to find other host cells where they can repeat the life cycle. The Body Fights Back As viruses begin to invade the body, a few are consumed by macrophages, which seize their antigens and display them on their own surfaces. Among millions of helper T cells circulating in the bloodstream, a select few are programmed to ;read; that antigen. Binding the macrophage, the T cell becomes activated. Once activated, helper T cells begin to multiply. They then stimulate the multiplication of those few killer T cells and B cells that are sensitive to the invading viruses. As the number of B cells increases, helper T cells signal them to start producing antibodies. Meanwhile, some of the viruses have entered cells of the body the only place they are able to replicate. Killer T cells will sacrifice these cells by chemically puncturing their membranes, letting the contents spill out, thus disrupting the viral replication cycle. Antibodies then neutralize the viruses by binding directly to their surfaces, preventing them from attacking other cells. Additionally, they precipitate chemical reactions that actually destroy the infected cells. As the infection is contained, suppresser T cells halt the entire range of immune responses, preventing them from spiraling out of control. Memory T and B cells are left in the blood and lymphatic system, ready to move quickly should the same virus once again invade the body. HIVs Life Cycle In the initial stage of HIV infection, the virus colonizes helper T cells, specifically CD4+ cells, and macrophages, while replicating itself relatively unnoticed. .ue25a387c383de9caaf6794d5d146da41 , .ue25a387c383de9caaf6794d5d146da41 .postImageUrl , .ue25a387c383de9caaf6794d5d146da41 .centered-text-area { min-height: 80px; position: relative; } .ue25a387c383de9caaf6794d5d146da41 , .ue25a387c383de9caaf6794d5d146da41:hover , .ue25a387c383de9caaf6794d5d146da41:visited , .ue25a387c383de9caaf6794d5d146da41:active { border:0!important; } .ue25a387c383de9caaf6794d5d146da41 .clearfix:after { content: ""; display: table; clear: both; } .ue25a387c383de9caaf6794d5d146da41 { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .ue25a387c383de9caaf6794d5d146da41:active , .ue25a387c383de9caaf6794d5d146da41:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .ue25a387c383de9caaf6794d5d146da41 .centered-text-area { width: 100%; position: relative ; } .ue25a387c383de9caaf6794d5d146da41 .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .ue25a387c383de9caaf6794d5d146da41 .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .ue25a387c383de9caaf6794d5d146da41 .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .ue25a387c383de9caaf6794d5d146da41:hover .ctaButton { background-color: #34495E!important; } .ue25a387c383de9caaf6794d5d146da41 .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .ue25a387c383de9caaf6794d5d146da41 .ue25a387c383de9caaf6794d5d146da41-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .ue25a387c383de9caaf6794d5d146da41:after { content: ""; display: block; clear: both; } READ: Cigarette Ad Essay As the amount of the virus soars, the number of helper cells falls; macrophages die as well. The infected T cells perish as thousands of new viral particles erupt from the cell membrane. Soon, though, cytotoxic T and B lymphocytes kill many virus-infected cells and viral particles. These effects limit viral growth and allow the body an opportunity to temporarily restore its supply of helper cells to almost normal concentrations. It .

Castle Rock Essay Essays

Castle Rock Essay Essays Castle Rock Essay Essay Castle Rock Essay Essay How is an Atmosphere of Fear and Evil Created in the Chapter ‘Castle Rock’ ? The ill-famed ‘Lord of the Flies’ chapter ‘Castle Rock’ : By the clip you reach the chapter â€Å"Castle Rock† . the children’s behavior is deteriorating. as they turn into barbarians. and get down attacking and stealing from each other to last in the ghastly wilderness. It is here that they expect that cipher will go to deliver and protect them from the malevolence from the dismaying island. The writer tries to pull strings and act upon the reader. He portrays an image that every dweller on the island has turned barbarian ; nevertheless this is non the instance. In fact ‘Piggy’ and Ralph are still sane. although it wholly destroys Ralph’s bosom. that Roger massacred ‘Piggy’ with the up-most aggression. Hence everybody chased him with repulsion to slay him with slug crisp wooden lances. All of this puts the readers’ head into overdrive. and makes the reader petrified. Cleverly by composing. ‘Ralph protested out of the bosom of civilisation’ Makes the reader feel sorry for Ralph in his despair. for all that he desires. which is peace. Furthermore. the reader even feels a small guilty. due to the fact that the reader can non make anything to assist Ralph in his ventures. The writer says. ‘Awful things have been done on this island’ . This insinuates that cryptic and violent transpirences occur twenty-four hours and dark. Some are noticed. and some are left unmarked. about as if it is the norm. or because it is top secret neer to be whispered to any other human psyche. This makes most of the kids want to utilize its unknown panic to do pandemonium. One illustration of linguistic communication and punctuation used in the chapter ‘Castle Rock’ is devised to make an ambiance of fright and immorality is. ‘The chill. silvern unreal laughter of the barbarians sprayed out and repeat off. A blast of fury shook Ralph! ’ When the writer says ‘unreal laughter’ it hints at something sinister and the fact that something immorality is in the ambiance around them. The writer makes it sound as if it is a normal and acceptable happening. because he doesn’t add any particular punctuation to it to do it sound more bloodcurdling than the mean twenty-four hours in ‘Castle Rock’ . Furthermore. the punctuation used in this quotation mark. ‘A blast of fury shook Ralph! ’ shows how ferocious Ralph is. by adding an exclaiming grade for accent. This makes the reader experience the fright of what Ralph might make. In other parts of the chapter. the writer creates confusion. which makes the reader think of the multiple waies that a specific portion of the chapter can take to. The writer uses his mastermind accomplishment to pull strings his description to hold more than one significance. One of the significances is to motivate fright. and the other is to convey hope into the Black Marias of the readers. Another illustration of linguistic communication and punctuation used is the quotation mark. ‘Then there was. there was†¦ that’s his mistake excessively. ’ When the writer writes ‘There was. there was’ . the words ‘there was’ are repeated to demo the anxiousness of the kids who are stating these words. Equally good as that. the writer says ‘†¦ that was his mistake too’ the eclipsiss used shows that what the kids had to state was excessively ghastly to articulate. The linguistic communication used shows that person has committed something so dismaying that it can non be mentioned and that it is something that terrifies the life daytimes out of them. In due class. I think that the fright and immorality has consumed the island. because it makes most of the kids resort to butchering hogs merely for merriment. because they have lost their artlessness and scruples. This is chiefly down to the fact that there is no jurisprudence. there is cipher to state them right from incorrect ; they think that they have the right to make anything that they desire. there is no construct of offense and penalty. This makes it about impossible for anybody to populate in peace or harmoniousness. Another ground is because in secret they are all frightened stiff of Jack. because he is the eldest and biggest. physically. and he has a powerful ally to contend for him and to protect him. known as Roger. nevertheless his biggest ally of all is fear itself. Ultimately. Jack wants to hold all of his enemies to populate in fright. so they slowly turn to him. because when they are fearful of him. they know that the longer they stay with Jacks figure one enemy. the worse their penalty would be if he were to capture them. So they finally turn to him for counsel and protection. Therefore. this makes him the ‘king’ of the island in a violent and barbarous manner.

A Strategic Analysis for Tim Hortons

A Strategic Analysis for Tim Hortons Presently, Tim Hortons is regarded as the leading publicly traded restaurant chain in Canada. Not only is it Canada’s leading quick-service restaurant brand but also the fourth largest publicly traded restaurant chain in North America based on market capitalization. They have the number one market share in breakfast and snacking day parts and a solid number two share in the lunch day part in Canada (1). However, Tim Hortons needs to pay more attention towards their growth and development into U.S. and other markets worldwide in order to become a true spearhead in their industry. Moreover, they can lessen the risks related with expansion by engaging in partnerships with other successful firms. Analysis/Rationale Although, as mentioned above, Tim Hortons is possibly the leading publicly traded restaurant chain in Canada, it enjoys its success due to its inhabitation of a much smaller market in comparison to markets in U.S., India, and China. To be the best of the lot, Tim Horto ns cannot exclusively depend on a single market. In this day and age, there are solid opportunities for them to become the world’s best, through new emerging markets with high probability for huge profits. There are increasing trends of coffee drinkers in China and India, two countries with enormous fondness for Western style drinks and meals and Tim Horton’s expansion in those countries will play to their advantage. That is the main reason why McDonalds, the equivalent quick service restaurant industry to Tim Hortons, is earning massive profits from both China and India. Entering into partnerships also ensures that the firms are able to share the risks of failure; thereby reducing their burden. Thus, the partnership of Tim Hortons with Kahala Corp is a great idea, since it links together both Tim Hortons and the Cold Stone Creamery concepts stores in U.S. In this situation, with the benefit of sharing risks of failure; in Kahala Corp, Tim Hortons have a partner who ha s enough knowledge about the U.S market, and how it works. Similarly, Tim Hortons need to ensure that they engage in further partnerships with other firms with the purpose of offering fresh and innovative Tim Hortons products that consumers are able to purchase outside of Tim Hortons stores. This move will evolve their brand image and their competitors will feel increased competitive pressure. Even with the motivation to expand globally, financing will be a tough challenge for Tim Hortons. Financial investments and cash are vital components needed to develop their brand image in other countries; however these investments can also turn out to be extremely risky. For that reason, engaging in partnerships will reduce their financial load and the overall risk. It is also very crucial for Tim Hortons to find vastly reputable and ethical firms to be linked with, since their image will be tied with those firms. Integrated Strategy The expansion of Tim Hortons should happen gradually with a ccuracy and precision. Since they already have a solid market share and leadership position in Canada, they need to form reasonable objectives and not have an enormous anticipation during the course of their global development. The strategy which Tim Hortons needs to follow when entering into China and India is broad differentiation strategy, due to the massive population. Majority of population in these two countries consist of people with low income; though it also holds a growing middle class. Attracting a wide range of customers and buyers would prove much more profitable for Tim Hortons instead of simply appealing to a niche market. So far, this approach has been effective for them in Canada, and it may as well assist them in foreign markets. However, substantial research of their prospective customers’ values, lifestyles and beverage preference must be completed before Tim Hortons enters into these new markets. In order to satisfy majority of the consumers in foreign ma rkets, items offered such as coffee, baked goods, other hot beverages, and meal items need to be redesigned according to consumers’ needs and fondness in the region/country they are living in. For instance, Tim Hortons should stock wide variety of teas and additional milk beverages in India, since majority of the people like to drink tea and other milk based beverages in that country. Moreover, not stocking up on breakfast items will lessen costs, since there isn’t a breakfast eating routine in India. Most people just drink tea there in the morning. Thus, this reduction in costs due to the lack of breakfast items in stock can be shifted to other areas.

Shange Essay Example | Topics and Well Written Essays - 750 words

Shange - Essay Example This is why Shan’ge was originally associated with agricultural work. The folk songs were always sung when people were working in the fields. This gave them morale to work harder (Titon 372). More importantly, the older societies like the jiu shehui sung the folk songs all through multifamily labor exchanges. This was principally during, hoeing, as well as, weeding corn, and a time they were sung while transplanting the rice shoots. The songs provided comfort for the workers. Additionally, the songs provided rhythm for the work, since some of the songs had counting off aspects which enable the farmers to have a certain rhythm while working. In history, the folksongs have also served a great deal in politics. This is especially in the 1910s and 1920s since they instilled solidarity and also helped in disseminating messages. This is because, by using familiar tunes, they were able to convey new words to the local people. Today, Shan’ge provides a window on historical experience and interaction of the people with the outside world. Despite the fact they are not as common as they were in ancient China, they play a huge role in enhancing heritage. Film music has impacted Chinese popular music in many ways. It is evident that the Chinese music provides the audience with utmost precedence to its melody (Titon 408). China is a country with a strong respect towards its forebears and ancestry and the film industry has enabled the people to uphold these aspects. It is therefore probable to find the film music of this kind of time still popular and known. For instance, the dragon dance and music is extremely familiar in the movie industry until today. There is an eminent root of film music in China. This is different from all other countries where the film music has no existing motifs or excerpts in the traditional aspects. This was not the case with China because the original music compositions emerging in films are growing till today. Popular music has grown intensively in china. Popular music started in the shidaiqu field and it was founded by Li Jinhui in China mainland. This popular music was highly influenced by Western jazz m usicians such as Buck Clayton. This was immediately after the implementation of the Communist Party. The popular music flourished greatly in Baak Doi, China where a record company was established. Cantopop was also influenced and this was in Hong Kong. Pop music in mainland China had been banned because it promoted unethical values which were against the communism values. However, the genre was revived in mainland China immediately after Deng Xiao Ping’s marketing reform. This is has influenced China's music diversity pop music combined with classical music. This is just like majority modern nations in the present day. Consequently China has grown to be one of the biggest producers of diverse music types while maintaining their traditional values (Titon 407-409). This is a traditional Chinese type of music and it utilizes the following instruments: daluo, bangu, tonngu, dabo and suona among others. Additionally, it is characterized by the following qualities. The music is sun g without reference to the notation by the musicians transferring it to the ensemble’s double-reed instrument. The melody is converted to vocal melody using grace notes. The music also has syllables that are compressed to feature into the percussion patterns (Titon 592). Beiguan musicians strive to consider each other as well as being inclusive in their performance activities. This is because of the fact that they usually see themselves as members of the same community association. The male members call each other

Parliamentary Sovereignty Essay Example | Topics and Well Written Essays - 1500 words

Parliamentary Sovereignty - Essay Example The constitutional status and the political role of the judiciary have been substantially altered by the European Communities Act 1972 and the Human Rights Act 1998. When England took up the membership of the European economic committee in 1973, the authority of judiciary improved significantly.As such, the authority to assess and deny parliamentary statutes was bestowed upon the judiciary, under circumstances when the statutes were not in compliance with community law. In particular, the European Communities Act 1972 gave legal effect to the subjection of the UK to existing and future Community law. This indicated acceptance of the direct applicability and supremacy of Community law over domestic law. Consequently, the domestic courts were conferred with important powers and jurisdiction.Although parliamentary sovereignty ensures that the British parliament, can at any point of time rescind the authority of EU law, by taking drastic measures, even to the extent of withdrawing from t he EU, it is now not economically or politically viable to take such an extreme decision and face the repercussions of doing so. The European Communities Act 1972, at Section 2, enjoins that every piece of parliamentary legislation has to be construed and applied in compliance with Community law. Hence, English law has to be interpreted as being subject to the principle of supremacy of Community law.For example, in Van Gend en Loos, it was held that a new legal order had come into existence, due to the Community.

e-Commerce web solutions Essay Example for Free

e-Commerce web solutions Essay Ecommerce stores that have been uniquely designed and developed with rich features have created success for online merchants from across diverse industries. With Agile project management and 10+ years of development experience, we deliver a go live version soon to help our customers start generating revenue as soon as possible. Attractive and easy user interface design is the expertise of the talented team and developing the required features. We have been successfully delivering e-stores that are highly appreciated by our clients as well as the customers who shop with them. While developing, the key focus remains on the aesthetics of the store which eventually attracts customers, gives them a smooth shopping experience and increases the chances of making a purchase. Once an ecommerce portal solution is up and running, it is then time to make sure that the general public knows about the ecommerce website and the business. This can happen with the help of search engine promotion for an ecommerce website which is not same as a normal static website. Since the site has got dynamic pages and products, a different strategy has to be worked upon in order to achieve the publicity results. Kenovate Solutions has been delivering the ecommerce search engine optimization services along with the development and hence have been a perfect choice for one-store-shop for ecommerce development and search engine optimization. With over 100+ websites developed, 40+ application software delivered and 50+ live sites hosted for a range of industries and verticals over the last 10+ years, Kenovate Solutions is serving web solution needs for early adopter entrepreneurs, startups and SMEs in domestic international web domain. Kenovate Solutions specializes in developing web portals, intranets, e-commerce solutions, and web / online applications those are used to streamline functionality and ease of use. Kenovate’s clients include a wide range of domains such as education, finance, FMCG, healthcare, hospitality, international development agencies, manufacturing, non-governmental, research agencies, real estate, retail, travel and tourism etc.